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Semaglutide, Tirzepatide, and Retatrutide: Mechanistic Differences in Research Context Although these compounds are often grouped together in discussion, they are pharmacologically distinct

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[1] [2] Sermorelin similarly lacks a current UK marketing authorisation for any adult indication and is not listed in the BNF as a licensed medicine

The LEADER, REWIND, and SUSTAIN-6 trials of respective liraglutide 1.8 mg/daily (or maximum tolerated dose), once-weekly dulaglutide 1.5 mg, and once-weekly semaglutide 0.5 mg or 1.0 mg administration in patients with type 2 diabetes and cardiovascular disease or risk factors found decreased hazard ratios ranging from 0.74 to 0.88 for the primary composite endpoint first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke [112114]

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