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Venous insufficiency, where leg veins struggle to return blood to the heart, commonly causes lower extremity swelling

Retrieved from Collins, L

This is because tirzepatide is not just a GLP-1 receptor agonist but also a GIP receptor agonist, making it more potent in some respects and potentially more likely to cause gastrointestinal side effects in the early weeks
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The combined effect produces stronger results than single-receptor medications in clinical studies
