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The side effect profile looks similar to other GLP-1 drugs, with nausea being the most common complaint

The net effect of ERR activation is increased mitochondrial mass and function, enhanced oxidative capacity, greater fatty acid utilization, and improved metabolic flexibility

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Slow, careful dose titration significantly reduces GI side effect burden patients who rush titration have considerably higher rates of intolerance

"The weight loss in clinical trials is even more substantial, and the most likely reason that it decreases orthopedic problems is because of the weight loss less stress on the joints and the decreased inflammation," Siegel added