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Common side effects include nausea, vomiting, diarrhoea, abdominal pain, and reduced appetite, especially when starting or increasing the dose

Usage Trends and Popularity Both medications became highly popular because obesity treatment demand continues growing

In the skeletal muscle, leptin increases muscle mass and enhances fatty acid oxidation through activating the JAK2-STAT3, AMPK and insulin-like growth factor I (IGF-1) signaling [130, 221], [222], [223]

Accordingly, while the direction of effects appears broadly consistent across systems, the precision of the estimated magnitudes should be interpreted with caution

However, it is sometimes used by healthcare providers for this indication