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In a phase 2 trial published in The New England Journal of Medicine , retatrutide produced substantial, dose-dependent weight reduction in adults with obesity over 48 weeks

Over a shorter timeframe of just 48 weeks, participants experienced unprecedented reductions: 12 mg Maximum Dose: Achieved an astonishing average of 24.2% total body weight loss in 48 weeks

Int J Mol Sci 16 , 62816297, (2015)

CVOTs In response to FDA guidelines requiring the assessment of anti-diabetic therapeutics in relation to cardiovascular risk, several CVOTs have been performed

Knowing what to expect at each phase prevents two common mistakes: getting discouraged early when the scale moves slowly, and getting impatient mid-treatment when the rate of loss naturally slows