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The -catenin-dependent signaling pathway is initiated by the binding of the wingless-type MMTV integration site family (WNT) 1, WNT3a and WNT10b to secreted frizzled-related protein (SFRP) 1 and SFRP5 and low density lipoprotein receptor-related protein (LRP) 5 and LRP6 receptors

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There was a reduction in plasma glucose and HbA1c levels at the three highest doses of retatrutide and a dose-dependent reduction in body weight [63]