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For now, patients who are taking semaglutide or considering treatment should discuss the risks and benefits with their doctors, especially those who have other known optic nerve problems such as glaucoma or preexisting visual loss, experts say It is important to consult with ophthalmology if patients experience visual changes, Narang said

When a DPP-4 inhibitor is added to a sulfonylurea regimen, the sulfonylurea dose may need to be reduced Pioglitazone offers similar glycaemic efficacy to gliptins but is associated with fluid retention and fracture risk DPP-4 inhibitors are generally considered weight-neutral , which is an advantage over sulfonylureas and insulin

As such, reducing insulin resistance and supporting healthy weight are important goals in the overall treatment and management of PCOS ( 1 , 3 )

The challenge is determining whats actually causing those symptoms, Salkin said

However, because FAERS does not account for total prescription volume, these differences should be interpreted cautiously and not as definitive risk comparisons