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Alcohol also increases blood sugar variability and can trigger insulin resistance, which works against the glucose-stabilizing effects of GLP-1 therapy

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Biochemical and Biophysical Research Communications Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding : Projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons

Patients finally have an obesity treatment available to them that actually works -- but because of ongoing challenges with supply -- they have to literally hunt down their medication, sometimes calling every pharmacy in their city just to come up empty