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16 Demonstrated clinical benefits of GLP-1s include improved cardiometabolic risks, fewer major adverse cardiovascular events, 22 decreased mortality in heart failure, 23-27 and improvements in obstructive sleep apnea, 11,28 prediabetes, 29,30 chronic kidney disease, 31 knee osteoarthritis, 32 substance use disorders, 33 and metabolic-associated steatotic liver disease
