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As GLP-1 receptor agonists, these peptide drugs mimic the incretin hormone GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appetite [9]

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Inducible whole-body Pam knockout mice were generated

The discovery of the therapeutic targets the receptors for incretins such as GLP1 and GIP is the revolution in this field.