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The pooled analysis revealed that the incidence of colorectal cancer was not significantly associated with GLP-1 RAs compared to other drugs (OR: 1.73 [0.2114.18], p = 0.61, I2 = 100%), as shown in Fig

In summary, the pipeline war takes many forms: head-to-head competition of existing drugs (Novo vs Lilly), acquisitions of emerging candidates, and licensing deals for novel modalities

Manufacturer patient assistance programs often provide substantial savings for qualifying patients

If weight is lost in a more gradual way, these changes may not be as noticeable

Health systems and clinicians should evaluate how these changes affect patient demand, prescribing patterns, and care coordination, while remaining alert to further guidance from CMS and the FDA as demonstration models unfold.