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Thus, the widely distributed brain GLP-1R populations are likely to primarily respond to the endogenous GLP-1 delivered by the PPG neurons

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A recent meta-analysis of randomized trials in obesity and/or diabetes found no increased risk of psychiatric adverse events, with improvements in quality of life, restrained eating, and emotional regulation measures (204)

The data indicates that approximately 60% of the lost weight is regained within a year of discontinuing the drug

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