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Amycretin's T2D data is from a phase 2 trial with shorter duration

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Sanyal ESSENCE is an ongoing phase 3 randomized controlled trial that enrolled 1,197 adults aged 18 years and older with histologically diagnosed steatohepatitis, stage 2 or 3 liver fibrosis and a nonalcoholic fatty liver disease (NAFLD) activity score of 4 or higher

It slows down gastric emptying, which can have a big effect on digestion

patients should report right upper quadrant pain, fever, or jaundice Diabetic retinopathy complications : Rapid glycemic improvement may temporarily worsen retinopathy in susceptible patients Acute kidney injury : Usually secondary to dehydration from gastrointestinal side effects Hypoglycemia : Particularly when combined with insulin or sulfonylureas Altering the prescribed dose through cutting or splitting makes it impossible for healthcare providers to accurately assess whether adverse effects are dose-related and how to appropriately adjust therapy