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The incretin system has become an important target in the treatment of type 2 diabetes in recent years, and glucagon-like peptide 1 (GLP-1) is of particular interest for its glucose-lowering effects

Thomas Kruse and Sren stergaard reflect on the development of the GLP-1 analogue, semaglutide, which is reshaping peptide therapeutics in type 2 diabetes, weight management, and beyond.

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For example, overweight and obese T2D patients treated with activin type 2 receptor antagonist bimagrumab in a phase 2 trial achieved net weight loss, comprising significant loss of total body fat mass while gaining some lean mass (i.e

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