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While AEs associated with these agents have been investigated 19,36,37 , our analysis reveals critical gaps in understanding their NAEs given the central nervous system penetration and expanding indications of GLP-1 RAs

This discrepancy in clinical recommendations underscores the critical need for comprehensive real-world evidence studies to elucidate the safety profile and adverse reaction patterns associated with combination therapy

Food and Drug Administration (2024) Alcohol Use Disorder: A Comparison Between DSM-IV and DSM-5 National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2025 AMA Report on Substance Use and Treatment American Medical Association (2025) Surf City Detox Surf City Detox Medical Team

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