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The main disqualifiers are a history of Medullary Thyroid Cancer, MEN 2 syndrome, or a prior history of pancreatitis

Drugs that are used to treat depression, schizophrenia, and other mental conditions can induce fatigue, lethargy, and weakness, sometimes resulting in leg cramps
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Jenkins TP, Rathnayaka Y, Perera PK, Peachey LE, Nolan MJ, Krause L, Rajakaruna RS, Cantacessi C
