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de van der Schueren MAE, Laviano A, Blanchard H, Jourdan M, Arends J, Baracos VE

Obes Pillars 15:100181 [DOI] [PMC free article] [PubMed] [Google Scholar] 43.Johnson B, Milstead M, Thomas O, McGlasson T, Green L, Kreider R et al (2025) Investigating nutrient intake during use of glucagon-like peptide-1 receptor agonist: a cross-sectional study

N Engl J Med 2025;393:1796-1806 [9] Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial, December 2025: Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial | Eli Lilly and Company [10] Fourth High-level Meeting of the UN General Assembly on the prevention and control of NCDs and the promotion of mental health and wellbeing (HLM4), September 2025: [11] Thousands of patients from Scotlands poorest areas to benefit from landmark UK government-funded obesity study, November 2025: Thousands of patients from Scotlands poorest areas to benefit from landmark UK government-funded obesity study - GOV.UK [12] Non-Traditional Channels: The Compounded GLP-1 Market

The combination can produce severe constipation that goes beyond mere discomfort into territory that affects quality of life and medication compliance