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This outcome included the effect of weight loss medication use, reaching clinically significant weight loss thresholds defined as loss of 5%, 10%, and 15% of baseline weight
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These trials, including STEP-1 through STEP-6, highlighted semaglutides superiority over placebo and other treatments, such as liraglutide, in promoting weight loss and enhancing cardiometabolic parameters, including blood pressure and lipid profiles [6][15]

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