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If split dosing allows them to eat normally throughout the week while maintaining adequate appetite suppression, the quality of weight loss might actually improve

Proc Natl Acad Sci U S A 101:1571815723

In practice, these doctors almost certainly will not have prescribed either agent, unless they have prescribed them privately

This 25 % body weight reduction resulting from a staged approach with 12-week intensive lifestyle intervention followed by tirzepatide is the largest reduction seen in GLP-1 trials to-date
