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Usage During Pregnancy: The safety of GLP-1 medications during pregnancy is not well established, necessitating caution and consultation with a healthcare provider

In addition, GLP-1 therapies affect body composition by reducing not only fat mass but also lean mass, a concern that is particularly relevant for at-risk groups such as older patients and those with sarcopenic obesity [[7], [8], [9]]

Until those results are in, the recommendation is extrapolated from non-pharmacologic weight-loss literature plus 2024-2025 case reports of GLP-1 patients who lifted and held their lean mass [11]

Results from the 2019 National Survey on Drug Use and Health: Detailed Tables