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Furthermore, recent finding reported that GLP-1 RAs significantly reduced C-reactive protein (CRP) levels in obese IBD patients, alongside a nearly statistically significant reduction in fecal calprotectin (100)

This cellular response may eventually lead to the death of DA cells, leading to disease progression.180 A study that used 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) to mimic PD-like neural injury found that neuroinflammation is aggravated in the midbrain of type 2 diabetes mice, who are more susceptible to the neurotoxicity induced by MPTP.181 This may indicate that diabetes exacerbates DA neuronal degeneration during the progression of PD, which may be mediated by neuroinflammation

In these cases, microdosing provides a lighter approach to achieve comparable benefits