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Description
By contrast, linagliptin and alogliptin bind within the enzyme's catalytically active pocket through interactions with both the S 1 /S 2 and S 1 '/S 2 ' binding sites, which are formed by a combination of aromatic amino acids, including Phe357, Tyr547, Tyr631, Tyr666, Trp629, and His740
Xiao et al ., 2001)
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But molecules that activate PPARs often have side effects
This prescribed medication works by helping regulate hunger, promoting a feeling of fullness, and reducing appetite
