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Clinical studies have shown topiramate can produce weight reductions of 5 to 10 percent of body weight over several months, making it significantly less potent than GLP-1 receptor agonists

[DOI] [PubMed] [Google Scholar] 25.Jensen SBK, Srensen V, Sandsdal RM, Lehmann EW, Lundgren JR, Juhl CR, Janus C, Ternhamar T, Stallknecht BM, Holst JJ, Jrgensen NR, Jensen JB, Madsbad S, Torekov SS

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Renoprotective effects of the combination of empagliflozin and liraglutide compared with Roux-en-Y gastric bypass in early-stage diabetic kidney disease: a post hoc analysis of the microvascular outcomes after metabolic surgery (MOMS) randomized controlled clinical trial