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In addition to heterogeneity, potential sources of bias must be considered, particularly in observational studies assessing treatment persistence and real-world effectiveness

Patients should be informed that a modest heart rate increase is an expected effect of GLP-1 therapy and does not typically indicate a problem

A.et al (2022)

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Long-term cost-effectiveness of subcutaneous once-weekly semaglutide versus polyethylene glycol loxenatide for treatment of type 2 diabetes mellitus in China
