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If someone is struggling with persistent nausea or diarrhea at their current dose, the provider can hold or even temporarily reduce the dose rather than pushing forward

Eating slowly and chewing thoroughly also helps your digestive system process meals without triggering nausea

The tradeoff is that semaglutide generally produces slightly less weight loss than tirzepatide in clinical comparisons, as tirzepatide is a dual GIP/GLP-1 agonist while semaglutide only targets GLP-1

Lifestyle Modifications: Diet quality and physical activity significantly impact outcomes