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1 Dose strength Rybelsus: lowmoderate daily doses for glucose control Oral Wegovy: much higher daily dose to match injectable Wegovy exposure With oral bioavailability at ~1%, obesity efficacy simply requires more drug not interchangeable

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In ASCVD, semaglutide has demonstrated significant reductions in major adverse cardiovascular events, supported by findings from meta-analyses of trials in patients with T2DM and the SELECT trial for patients without T2DM