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Risk of Retained Gastric Contents in Patients Using GLP-1RAs or Tirzepatide Presenting for Endoscopy or General Anesthesia Retrospective studies suggest that individuals on GLP-1-based therapy (exenatide, liraglutide, dulaglutide, semaglutide, or tirzepatide) appear to be at an increased risk of having retained gastric contents [Supplementary Table S3 (21)

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Other potential contributors include dehydration and reduced caloric intake

It is well known that increased glutamate levels are associated with increased neuronal activity, leading to glutamate-induced excitotoxicity via reactive oxygen species (ROS) production [65, 66]