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So far, several unimolecular dual and triple agonists are in clinical evaluation and as of today, the improved metabolic efficacy does not seem to be compromised by reduced safety [25].

Dosage: Starting dose of 1.5 mg

doi: 10.2337/diabetes.48.12.2270 [DOI] [PubMed] [Google Scholar] 130

Proc Natl Acad Sci U S A (1989) 86:760610

The two-year safety profile largely resembled the one-year profile, which was reassuring for the framing of GLP-1 therapy as chronic treatment rather than a finite intervention