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The MR-Egger intercept method ( P = 0.0882) and the MR-PRESSO Global test method ( P = 0.325) both demonstrated that there was no horizontal pleiotropic effect on the causal association of the genetic proxy GLP-1RA with DR, suggesting that the tool variable was not significantly influencing the outcome through pathways other than exposure

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In practice, many women experience more regular menstrual cycles after several months of metformin therapy

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed for type 2 diabetes management and now widely prescribed for chronic weight management