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Clin Med

Phase 2 and phase 3 clinical trials for MASLD/MASH with GLP-1 receptor agonists and glucagon/GIP/GLP-1 receptor dual or triple agonists, using biopsy to assess hepatic endpoints, are summarised in Table 1

Moreover, withdrawal of Retatrutide led to weight gain and the restoration of oxidative phosphorylation and glycolysis, indicating that the metabolic effects of GLP-1R agonists are short-lived

At the same time, pharmaceutical companies are putting serious money into R and D, trying to bring in next-generation therapies and make results more consistent for patients

Regular monitoring is essential for patients on GLP-1 therapy