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The Harmony Outcomes post-hoc analysis also showed a similar trend with respect to MACE and HHF, although kidney outcomes were not examined (Table 3) [48]

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The body, he said, adapts to weight gain but doesnt adapt to weight loss

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Additionally, a pooled analysis of large-scale clinical studies evaluating the cardiorenal advantages of GLP-1RAs in T2DM suggested a trend towards reduced pulmonary adverse events, including asthma, in the GLP-1RAs treatment groups [256]

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Suboptimal Treatment Response with AOMs Once a treatment has been initiated, it is important to consider what to do in the event of a suboptimal treatment response

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However, FXR activation decreases both proglucagon mRNA levels and GLP-1 secretion in response to glucose [175, 176]

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