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In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%

Understanding the Mechanism: How GLP-1 Could Affect Hair Health While a definitive mechanism connecting GLP-1 medications to hair loss remains elusive, researchers speculate that the rapid weight loss often associated with these drugs plays a significant role

Plaintiffs argue that the same physiological effect that improves blood sugar control, delayed digestion, may also contribute to severe medical events in vulnerable patients

Extended constipation can also lead to reactive diarrhea
