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In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%

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Understanding the Mechanism: How GLP-1 Could Affect Hair Health While a definitive mechanism connecting GLP-1 medications to hair loss remains elusive, researchers speculate that the rapid weight loss often associated with these drugs plays a significant role

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Plaintiffs argue that the same physiological effect that improves blood sugar control, delayed digestion, may also contribute to severe medical events in vulnerable patients

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Extended constipation can also lead to reactive diarrhea

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