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In addition, a metagenomic study in a T2D-treatment-nave Swedish cohort has shown that microbiota composition is altered in IGT and CGI, and is characterized by a reduction in the abundance of butyrate-producing bacteria and the terminal genes for butyrate synthesis (43)

Greater insulinotropic action of oral glucose relative to its peripheral administration was demonstrated for both normal weight and obese individuals [63] and henceforth became known as the incretin effect [64,65]

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Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, et al

Infiltration of immune cells can result in IFP inflammation