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In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy

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Yermek, R., Wang, L., Kaneko, K., Han, W., Seino, Y., Yabe, D., & Yada, T

Semaglutide and cardiovascular outcomes in patients with type 2 diabetes