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41% lower obesity-related cancer incidence over ~2 years

Boland BB, Laker RC, OBrien S et al (2022) Peptide-YY(336)/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic beta-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries

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The authors suggest this may reflect a dysregulated incretin system that was not overcome by pharmacological doses of the drugs within six months

doi: 10.1016/j.surg.2010.11.015 [DOI] [PMC free article] [PubMed] [Google Scholar] 21.Park AM, Storm DW, Fulmer BR, Still CD, Wood GC, Hartle JE, II