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Opened pens that are in use can be kept in the refrigerator or in a cool space between 59 degrees F and 86 degrees F, according to manufacturer guidelines

Quantitative sensory testing showed mildly elevated thermal detection thresholds in a nonlength-dependent and asymmetric pattern that was inconsistent with small-fiber neuropathy

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However, they may also be beneficial for those struggling with impulse control issues or addictive behaviors