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Analysis revealed that among patients receiving the highest dose of tirzepatide treatment, 73.9% achieved the trial's primary endpoint, with NASH symptoms resolved and liver fibrosis not worsening after 1 year of treatment [10]
It was confirmed that GLP-1 increases insulin secretion from pancreatic -cells in a way that is dependent on glucose levels, while simultaneously decreasing GCG production [93], [94], [95] Additionally, they enhance insulin sensitivity [96] and delay stomach emptying, which is useful in obesity [97]
Excess hepatic fat accumulation triggers a cascade of metabolic disturbances that can impair liver function over time
This was the highest average increase observed across any dose group at any time point
2004;53((Suppl
