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More serious effects that FDA labeling flags for this drug class include pancreatitis risk, thyroid C-cell changes (observed in animal studies), gallbladder disease, and hypoglycemia risk in patients combining GLP-1 agonists with insulin or sulfonylureas
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Heart Failure, Saxagliptin, and Diabetes Mellitus: Observations from the SAVOR-TIMI 53 Randomized Trial

NPR reveals that pharmacists are even running out of the GLP-1 Trulicity (dulaglutide) which is approved strictly for diabetes but can be used off-label for weight loss

doi: 10.1016/S0140-6736(75)92375-2 48 CryerPE
