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Description
Retatrutide activates GIPR and GCGR , achieving over 20% weight loss in phase 2 trials
The clinical development program included multiple phase 1, 2, and 3 trials evaluating safety, efficacy, and optimal dosing strategies in diverse patient populations
It also increased whole-body energy expenditure in mice fed a high-fat diet and enhanced the conversion of the essential amino acid arginine into ornithine and citrulline
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The GLP-1R/GIPR/GcgR triple-agonist retatrutide achieves body weight loss (~25%) in just two-thirds of the time, potentially surpassing the efficacy of Roux-en-Y gastric bypass [29]
