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Conclusions Regarding the controversy of whether GLP-1based therapy can increase the risk for specific malignant disease like pancreatic carcinoma and thyroid cancer, our conclusion is that apparently there is neither firm evidence in favor of this hypothesis nor evidence strong enough to rule out any such increased risk based on results available at present

That is, the ADA recommends that one of these agents be considered as add-on therapy irrespective of the need for glucose lowering

Prescription medication is prescribed at a medical providers discretion if clinically appropriate

New England Journal of Medicine 3731122

Testosterone: The gradual decline of testosterone (yes, women have it too!) can cause a loss of lean muscle mass
