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In a matter of three months, one study showed a median weight reduction of 6.6% of their original weight

Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy

These mice had less pain, less broken-down cartilage and more cartilage growth, the team found

However, many patients can benefit from lower doses (1-2 mg), though nausea can be a common side effect 1

What the evidence shows The most useful single piece of evidence is a 2022 meta-analysis in JAMA Internal Medicine that pooled 76 randomised trials covering more than 100,000 participants
