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The mechanism of action involves multiple pathways

Small molecule programs remain high risk high reward Pfizers pullback from its own oral GLP-1 programs has highlighted a major scientific challenge: biased agonism can improve GI tolerability but does not eliminate hepatotoxicity risk

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Indeed, the model values are all within 1% of the data for the relative change in body weight across placebo, 5, 10, and 15 mg doses of tirzepatide measured at 11 time points over the 72 week study

Ongoing clinical trials will provide evidence of clinically meaningful outcomes regarding the effects of GLP1-RAs in individuals with T2D [65]