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However, currently available data indicate that this disinterest in high-calorie products (and overconsumption of food in general) is reversible and that stopping treatment quickly leads to a regain of most of the weight initially lost

Discontinuation of GLP1RAs and tirzepatide typically results in weight regain, deterioration of glycaemic control and the loss of previous improvements in cardiometabolic markers

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However, guidelines uniformly emphasize that medication must be used alongside continued diet and exercise counseling