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Weight gain and weight loss is a complex interaction of multiple hormones, says Mir Ali, MD, the medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California

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A low basal metabolic rate is a risk factor for increased body weight and fat mass 35

The short answer is yes, it is generally considered safe to switch from tirzepatide to semaglutide, provided the transition is managed by a licensed healthcare professional
