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The American Urogynecology Society reviewed 43 publications (39 studies

However, some patients benefit from switching to alternative GLP-1 compounds or dosing protocols that produce gentler weight loss trajectories

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Early research suggests GLP-1 receptor agonists may modulate immune responses relevant to autoimmune conditions, but clinical evidence is preliminary

Whilst the use of DPP-4 inhibitors may theoretically support weight loss in the treatment of obesity through increasing the half-life of endogenous GLP-1, weight loss associated with their use is clinically insignificant (0.160.64 kg) [29], and as such their use in obesity is not explored further in this manuscript