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Traditional concerns about glucagon (hyperglycemia) are mitigated by the simultaneous GLP-1/GIP activation, which suppresses glucagon's negative metabolic effects while preserving its beneficial thermogenic actions

Kalwitz, G., Andreas, K., Endres, M., Neumann, K., Notter, M., Ringe, J., Sittinger, M., & Kaps, C

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This narrative mini-review aims to describe the involvement of the GH/IGF-1/IGF-1R axis in either mediating or responding to the effects of each of the two drug classes