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13 Two meta-analyses of other GLP-1 RA CVOTs found that GLP-1 RAs were associated with greater rates of DR progression, but both studies found that the effect was driven by the extent of hemoglobin A1c reduction, rather than the medications themselves

Available at: [Source for Engs $8,000 personal investment] Schwarcz J

There was no difference between the groups in the number of procedural complications or adverse events

GLP-1 receptor agonist intolerance refers to a situation where side effects become severe enough that a patient cannot continue treatment comfortably

GLP-1 receptor agonism is also achieved by inhibitors of dipeptidyl peptidase-4 (DPP-4), which prevent the inactivation of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), thereby prolonging their raised levels after meal ingestion