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Description
The approval was based on data from two randomized, double-blind, placebo-controlled studies involving more than 3,000 overweight or obese adults
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In addition to providing a pharmacokinetic profile that enables once-weekly dosing, the acylation moiety of tirzepatide also contributes to the interaction with both the GIPR and GLP-1R, as well as possibly the cell membrane 50
As far as duration is concerned, although any amount of activity is better than none, its best to start slow and work up to 30-60 minutes of activity a day (at least 3 days per week dedicated to cardiovascular work), at increasing levels of intensity
This hypothesis has not been tested for retatrutide but is supported by data from other nasally delivered GLP-1 agonists
