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In a mouse model of osteoarthritis induced by destabilization of the medial meniscus, glycoursodeoxycholic acid was found to mitigate disease progression, an effect associated with an increase in intestinal L cell numbers (87)
Similarly, the STEP-6 study 25 reported a 3% incidence of psychiatric events with semaglutide 2.4 mg, compared to 1% in the placebo group
Mehta R, Billings LK, Liebl A, Vilsbll T
