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In T2DM, variations in IR, -cell function, and tissue-specific GLP-1R expression (pancreas, liver, adipose) create diverse metabolic niches that influence the biodistribution and pharmacodynamics of nanocarriers [514516]
Drugs such as Ozempic, Wegovy, and Zepbound have helped millions of people achieve significant weight loss, improve metabolic health, and reduce the risk of chronic diseases
It avoids first-pass liver metabolism, which means lower risk of blood clots and a better lipid profile compared to oral estrogen
In our experiment, berberine stimulation increased the expression of related molecules in the GLP-1/GLP-1R/PKA signaling pathway in MIN6 cells
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